H1N1 Influenza Center

From the Publishers of the New England Journal of Medicine

Flu Activity Levels Off, but CDC Official Warns Against ‘Complacency’ Flu Activity Levels Off, but CDC Official Warns Against ‘Complacency’

February 8, 2010 • COMMENTS (0)

“H1N1 flu activity seems to have leveled off,” according to the CDC, but vaccination “remains a good idea.” (more…)

Responses to 2009 H1N1 Vaccine in Children 3 to 17 Years of Age Responses to 2009 H1N1 Vaccine in Children 3 to 17 Years of Age

December 30, 2009 • COMMENTS (1)

CORRESPONDENCE
Responses to 2009 H1N1 Vaccine in Children 3 to 17 Years of Age
A. Arguedas, C. Soley, and K. Lindert

These preliminary data support the use of one 15-μg dose of 2009 H1N1 vaccine without adjuvant in children between the ages of 9 and 17 years. However, in children 3 to 8 years of age, only the 7.5-μg dose of 2009 H1N1 vaccine with adjuvant met both the immunogenicity criteria after one dose.

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Household Transmission of 2009 Pandemic Influenza A (H1N1) Virus in the United States Household Transmission of 2009 Pandemic Influenza A (H1N1) Virus in the United States

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ORIGINAL ARTICLE
Household Transmission of 2009 Pandemic Influenza A (H1N1) Virus in the United States
S. Cauchemez and Others

This study shows that when a member of the household became infected with the 2009 H1N1 influenza virus, household contacts less than 18 years of age were twice as susceptible to an acute respiratory illness as were those 19 to 50 years of age, whereas contacts older than 50 years were less susceptible.

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Case 40-2009 — A 29-Year-Old Man with Fever and Respiratory Failure Case 40-2009 — A 29-Year-Old Man with Fever and Respiratory Failure

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CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL
Case 40-2009 — A 29-Year-Old Man with Fever and Respiratory Failure
T.M. Uyeki, A. Sharma, and J.A. Branda

A 29-year-old man presented with fever and respiratory distress. He had fever, a nonproductive cough, and myalgias. On admission to this hospital, he was hypoxemic. Respiratory failure, renal failure, and hypotension developed.

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Certain H1N1 Vaccines Should Be Given by Feb. 15 Certain H1N1 Vaccines Should Be Given by Feb. 15

February 4, 2010 • COMMENTS (0)

All lots of Sanofi Pasteur H1N1 vaccine in prefilled syringes should be administered by February 15 because of concerns over reduced potency, the CDC reported on Wednesday. (more…)

Three Studies Demonstrate the Safety and Efficacy of Pandemic H1N1 Flu Vaccine Three Studies Demonstrate the Safety and Efficacy of Pandemic H1N1 Flu Vaccine

January 25, 2010 • COMMENTS (1)

Results are in from studies in the U.S., China, and Hungary. (more…)

Health Map

HealthMap

See an interactive map showing worldwide cases of H1N1 influenza. From HealthMap

Pandemic H1N1 News Center

H1N1 news: Jan. 19, 2010

On the White House Blog Saturday, Kathleen Sebelius encouraged Americans become a “Flu Fighter” on Facebook by installing the DHHS’s new Facebook app. “This application,” she wrote, “gives people a fun way to encourage friends and family to get vaccinated.” (1/16, The White House Blog)

About 1 in 5 Americans have been vaccinated against H1N1, according to the government’s first detailed estimates of vaccination rates. (1/15, AP)

Read Previous Pandemic H1N1 News

New England Journal of Medicine

Outbreak of 2009 Pandemic Influenza A (H1N1) at a New York City School

December 30, 2009 • COMMENTS (0)

ORIGINAL ARTICLE
Outbreak of 2009 Pandemic Influenza A (H1N1) at a New York City School
J. Lessler and Others

Once introduced into a high school in New York City, the 2009 H1N1 virus spread quickly among students and staff, with an influenza-like illness developing in more than 800 people during a 2-week period in April 2009.

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Journal Watch

Incidence and Case Fatality Rates of Novel 2009 Pandemic A/H1N1 Influenza in England

January 19, 2010 • COMMENTS (2)

H1N1 influenza incidence was highest among children, but H1N1-associated mortality was highest among elders. (more…)

Advice to Practitioners

Neuraminidase Inhibitors Have Only ‘Modest Effectiveness’ in Otherwise Healthy Adults with Flu

December 9, 2009 • COMMENTS (0)

Oseltamivir and zanamivir “have modest effectiveness against the symptoms of influenza in otherwise healthy adults,” according to a BMJ analysis published online. (more…)

News Updates

Travel-Associated H1N1 Influenza in Singapore

December 21, 2009 • COMMENTS (1)

Airport thermal scanners detected only 12% of travel-associated flu cases; many travelers boarded flights despite symptoms. (more…)

Surveillance Updates

WHO Addresses Vaccine Anaphylaxis, Drug Resistance, H1N1 Mutations

November 30, 2009 • COMMENTS (1)

The World Health Organization has addressed several 2009 H1N1 reports that have received a lot of press attention over the past week, including post-vaccination anaphylaxis, clusters of oseltamivir resistance, and an H1N1 mutation. (more…)

Original Research

Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China

December 9, 2009 • COMMENTS (0)

ORIGINAL ARTICLE
Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China
B. Cao and Others

In China an initial policy of quarantine was instituted, and the early cases of H1N1 were systematically monitored. In 426 of these early cases, the incubation period was 2 days, 72.8% of the patients had fever, and the duration of viral shedding was 6 days.

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Related editorial by N. Lurie: The Need for Science in the Practice of Public Health

Research Summaries and Commentary

Preparing for 2009 H1N1 Influenza

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EDITORIAL
Preparing for 2009 H1N1 Influenza
R.P. Wenzel and M.B. Edmond

Drs. Richard Wenzel and Michael Edmond write that the 4500 deaths from 2009 H1N1 influenza are approximately 2% of the 250,000 or more deaths seen worldwide from seasonal influenza each year. Nevertheless, no one should be complacent about an unpredictable virus capable of killing children and young adults in their prime.

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Related article by the ANZIC Influenza Investigators: Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand
Related article by S. Jain and Others: Hospitalized Patients with 2009 H1N1 Influenza in the United States, April–June 2009

Policy & Perspectives

The Emotional Epidemiology of H1N1 Influenza Vaccination

November 25, 2009 • COMMENTS (0)

PERSPECTIVE
The Emotional Epidemiology of H1N1 Influenza Vaccination
D. Ofri

Dr. Danielle Ofri describes the fascinating and frustrating shift in public sentiment over the course of the H1N1 epidemic.

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Review Articles

Online First June 29, 2009, from the New England Journal of Medicine

June 29, 2009 • COMMENTS (2)

ORIGINAL ARTICLES
Severe Respiratory Disease Concurrent with the Circulation of H1N1 Influenza
G. Chowell and Others
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Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
R. Perez-Padilla and Others
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CURRENT CONCEPTS
Historical Perspective — Emergence of Influenza A (H1N1) Viruses
S.M. Zimmer and D.S. Burke
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PERSPECTIVE
The Persistent Legacy of the 1918 Influenza Virus
D.M. Morens, J.K. Taubenberger, and A.S. Fauci
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CORRESPONDENCE
Spread of a Novel Influenza A (H1N1) Virus via Global Airline Transportation
K. Khan and Others
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Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans
D.J. Faix, S.S. Sherman, and S.H. Waterman
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Background

Online First May 27, 2009, from the New England Journal of Medicine

May 26, 2009 • COMMENTS (5)

PERSPECTIVE
Managing and Reducing Uncertainty in an Emerging Influenza Pandemic
M. Lipsitch and Others
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Geographic Dependence, Surveillance, and Origins of the 2009 Influenza A (H1N1) Virus
V. Trifonov, H. Khiabanian, and R. Rabadan
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Blogs

Diagnostic Testing for 2009 Pandemic Influenza A (H1N1) Virus Infection in Hospitalized Patients

December 2, 2009 • COMMENTS (9)

Establishing a diagnosis of 2009 pandemic influenza A (H1N1) virus infection in hospitalized patients can be challenging, especially in patients presenting late in their clinical course. (more…)

Pandemic H1N1 News Center

H1N1 news: Jan. 19, 2010

January 19, 2010 • COMMENTS (0)

On the White House Blog Saturday, Kathleen Sebelius encouraged Americans become a “Flu Fighter” on Facebook by installing the DHHS’s new Facebook app. “This application,” she wrote, “gives people a fun way to encourage friends and family to get vaccinated.” (1/16, The White House Blog)

About 1 in 5 Americans have been vaccinated against H1N1, according to the government’s first detailed estimates of vaccination rates. (1/15, AP)

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