H1N1 Influenza Center

A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza

CORRESPONDENCE
A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza
L.Q. Mai and Others
The authors report on a cluster of seven cases of oseltamivir-resistant 2009 H1N1 infection in Vietnam.
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H1N1 News: Nov. 13, 2009

New CDC numbers made public Thursday show that H1N1 has sickened about 22 million Americans since April and contributed to an estimated 4,000 deaths. (11/13, AP)
The WHO reported that emergency supplies of antiviral drugs are being sent to Ukraine, Afghanistan, and other countries in Eastern Europe and Central Asia. (11/13, NYT)

Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis

CORRESPONDENCE
Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis
D.N. Fisman and Others
The results indicate that a neuraminidase mutation (H275Y) is associated with oseltamivir resistance not only in seasonal H1N1 and avian H5N1 viruses but now also in 2009 pandemic H1N1 strains.
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CDC Releases ‘Quick Facts’ for Providers on Antiviral Drug Use

At Friday’s CDC press briefing on 2009 H1N1 flu, Dr. Anne Schuchat stressed the importance of antiviral drugs for severe illness and directed clinicians to a fact sheet on “some of the myths and misconceptions about antivirals.”

H1N1 News: Nov. 9, 2009

Seven H1N1 vaccination clinics held over the weekend in New York City had enough vaccine to accommodate 31,500 each day. However, the total amount administered was a less-than-expected 3,450. (NYT, 11/9)
A “skeptical minority” of physicians refuse to recommend the H1N1 vaccine to patients. (Wash Post, 11/8)
The Massachusetts Department of Public Health allowed a reporter to observe [...]

New CDC Interim Guidance on HIV and H1N1

HIV-infected individuals are a high-priority group for prevention and treatment of 2009 H1N1 influenza. (more…)

The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza

PERSPECTIVE
The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza
D. Birnkrant and E. Cox
On October 23 the FDA issued an Emergency Use Authorization for peramivir for the treatment of suspected or confirmed cases of 2009 H1N1 influenza. Drs. Debra Birnkrant and Edward Cox discuss the limited data on safety and efficacy and the [...]

President Obama Declares H1N1 a ‘National Emergency’

President Obama declared over the weekend that the 2009 H1N1 pandemic constitutes a national emergency.

Use of Ribavirin to Treat Influenza

CORRESPONDENCE
Use of Ribavirin to Treat Influenza
K.M. Chan-Tack, J.S. Murray, and D.B. Birnkrant
With the current H1N1 influenza pandemic, questions have arisen regarding the potential for ribavirin as a treatment option. These authors report that the published studies are inconclusive regarding the potential clinical benefits of the drug for the treatment of influenza.
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Online First September 30, 2009, from the New England Journal of Medicine

PERSPECTIVE
Novel H1N1 Influenza and Respiratory Protection for Health Care Workers
K.I. Shine, B. Rogers, and L.R. Goldfrank
Guidelines from the CDC recommend the use of an N95 filtering facepiece respirator. Drs. Kenneth Shine, Bonnie Rogers, and Lewis Goldfrank discuss the efficacy of personal respiratory protection measures, medical masks, and respirators.
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CORRESPONDENCE
CDC and FDA Response to [...]