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Enrolling Pregnant Women in Research — Lessons from the H1N1 Influenza Pandemic
PERSPECTIVE Enrolling Pregnant Women in Research — Lessons from the H1N1 Influenza Pandemic S.F. Goldkind, L. Sahin, and B. Gallauresi The global H1N1 influenza pandemic disproportionately affected pregnant women, drawing attention to the fact that they have always been a marginalized study population. Dr. Sara Goldkind and colleagues argue that it is imperative that pregnant [...]
Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection
MEDICAL PROGRESS Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza Illness caused by the 2009 H1N1 virus has occurred in almost all countries, with more than 16,000 deaths from laboratory-confirmed cases reported to the WHO. This review by WHO [...]
Procalcitonin and C-Reactive Protein Levels Might Help Detect Bacterial Infection in Patients with H1N1 Influenza
A combination of procalcitonin level >0.8 ng/mL and CRP level >200 mg/L had a 90% positive predictive value for distinguishing bacterial or mixed bacterial/H1N1 infection from H1N1 infection. (more…)
Steroids Might Benefit Critically Ill Patients with Suspected H1N1 Influenza
Combined treatment with antiviral agents and steroids led to significant improvements in organ function within 1 week. (more…)
Case 40-2009 — A 29-Year-Old Man with Fever and Respiratory Failure
CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL Case 40-2009 — A 29-Year-Old Man with Fever and Respiratory Failure T.M. Uyeki, A. Sharma, and J.A. Branda A 29-year-old man presented with fever and respiratory distress. He had fever, a nonproductive cough, and myalgias. On admission to this hospital, he was hypoxemic. Respiratory failure, renal failure, and [...]
A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza
CORRESPONDENCE A Community Cluster of Oseltamivir-Resistant Cases of 2009 H1N1 Influenza L.Q. Mai and Others The authors report on a cluster of seven cases of oseltamivir-resistant 2009 H1N1 infection in Vietnam. Full Text | PDF | Supplementary Material
Neuraminidase Inhibitors Have Only ‘Modest Effectiveness’ in Otherwise Healthy Adults with Flu
Oseltamivir and zanamivir “have modest effectiveness against the symptoms of influenza in otherwise healthy adults,” according to a BMJ analysis published online.
ECMO for Patients with 2009 H1N1 Influenza and ARDS
In a study from New Zealand and Australia, extracorporeal membrane oxygenation was used largely in young adults, most of whom had good outcomes. (more…)
Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis
CORRESPONDENCE Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis M. Baz and Others The results indicate that a neuraminidase mutation (H275Y) is associated with oseltamivir resistance not only in seasonal H1N1 and avian H5N1 viruses but now also in 2009 pandemic H1N1 strains. Full Text | PDF
CDC Releases ‘Quick Facts’ for Providers on Antiviral Drug Use
At Friday’s CDC press briefing on 2009 H1N1 flu, Dr. Anne Schuchat stressed the importance of antiviral drugs for severe illness and directed clinicians to a fact sheet on “some of the myths and misconceptions about antivirals.”
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